| 摘要 |
PURPOSE:To obtain the subject new physiologically active substances, having suppressing actions on the growth of a mammalian cell and useful as an active ingredient of an anticancer agent by culturing a microorganism, belonging to the genus Streptomyces and having the ability to produce the physiologically active substances NKl48198A and NK148198B. CONSTITUTION:This method for producing new physiologically active substances, NK148198A and NK148198B is to culture a microorganism, belonging to the genus Streptomyces and having the ability to produce the physiologically active substance, NK148198A or NK148198B [e.g. Streptomyces sp. NK148198 strain (FERM P-13962)] in a culture medium, produce and accumulate the formed product in the resultant culture and collect the prepared product. The physiologically active substances assume a white waxy appearance, are soluble in lower alcohols, chloroform and ethyl acetate and manifest the positivity to color reactions such as phosphomolybdic acid- sulfuric acid and ninhydrin reactions. Furthermore, the resultant physiologically active substances comprise the NK148198A expressed by the rational formula, C14H31N and the NK148198B expressed by the rational formula, C15H33N and are useful as an active ingredient of an anticancer agent. |
