摘要 |
PURPOSE:To obtain a novel compound which is excellent in carcinostatic action against human cancerous cells, particularly uterocervical cancer cells with reduced acute toxicity and can overcome the problems on microbial substitution because it has no antimicrobial activity. CONSTITUTION:This compound is carcinostatic antibiotic, thiazinotrienomycin A-E of formula I (R is cyclohexyl, cyclohexenyl; X is H, and Y and Z incorporate to form formula III and Z is H) or their salts, for example, thiazinotrienomycin A. The compound has the following physical/chemical properties: appearance: white powder; molecular formula: C38H49N3O8S; Solubility: soluble in chloroform, methanol, slightly soluble in water; acidic, neutral or basic discrimination; weakly acidic. The compound is obtained by culturing a microorganism producing the compound in Streptomyces such as Streptomyces sp. MJ672-m3 (FERM-P-14047) and separating from the culture mixture and purifying the product. |