| 摘要 |
PURPOSE:To obtain a new substituted cyclic amine compound having a strong and selective serotonin 2 receptor antagonistic effect and useful for prevention and therapy of hypertension, ischemic heart diseases, cerebrovascular diseases, etc. CONSTITUTION:A compound is expressed by formula I [A is CONR<4> or SO2NR<4> (R<4> is an alkyl, an alkenyl, an aralkyl, an acyl, phenyl, naphthyl, etc.); B is a single bond, CHOH or CO; D is CH, H or N(0); Q is CH or N; R<1> and R<2> are H, a halogen, an alkyl, an alkenyl, an alkoxy, a hydroxyalkyl, an alkyl- substituted or non-substituted amino, an acylamino, an amidino which may be substituted, a (thio)ureido which may be substituted, an azole, a carboxyl, formyl, etc.; R<3> is H, a halogen, a mono- or di-alkylamino; (n) is 2 to 6] or its salt, e.g. N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-3-methoxy-N-(2- methoxyphenyl)benzamide oxalic acid salt. This compound can be synthesized by reacting a compound of formula II with a compound of formula III. |
