| 摘要 |
<p>PURPOSE:To obtain the subject new compound which is a new lipid A analog, having beneficial activities such as immunopotentiating and antitumor actions, inducing actions, etc., on tumor necrosis factors, reduced in toxicity and useful as a medicine such as an immunopotentiator or an antitumor agent. CONSTITUTION:This new lipid A analog (salt) is expressed by formula I [R<1> is a group expressed by formula II {R<5> is hydroxyl group, an amino acid residue or a group expressed by the formula NH(CH2)t-R<6> [R<6> is OH, carboxyl, amino or an alkylamino; (t) is an integer of 1-4]}; R<2> is OH or, together with R<1>, denotes single bond; R<3> is H or a group expressed by formula III; (m) and (n) each is an integer of 5-17; (r) is an integer of 4-16] and has useful activities such as immunopotentiating and antitumor actions, inducing actions, etc., on tumor necrosis factors. Furthermore, the lipid A analog is reduced in toxicity and useful as an immunopotentiator, an antitumor agent, etc. The compound is obtained by acylating amino group at the 2-position of a compound, expressed by formula V (Ph is phenyl; R<8> is a protecting group of carboxyl) and derived from the glucosamines expressed by formula IV with a carboxylic acid compound containing hydroxyl group.</p> |
