| 摘要 |
PCT No. PCT/SE95/00249 Sec. 371 Date Oct. 23, 1996 Sec. 102(e) Date Oct. 23, 1996 PCT Filed Mar. 9, 1995 PCT Pub. No. WO95/25534 PCT Pub. Date Sep. 28, 1995A solid pharmaceutical composition for oral administration of small and medium size peptides, particularly vasopressin, oxytocin, and their analogues, comprises said peptide, an enteric coat and a pharmaceutically acceptable carrier containing a buffering agent buffering at a pH of from 2 to 6, preferably at about pH 5. A method of manufacture of single doses of said peptide comprises mixing of the ingredients, forming the resulting mixture into spheres smaller than 2 mm, coating the spheres with an enteric coat which is readily soluble in gastric juice of pH 5.0 or higher but not at substantially lower pH, and filling the coated spheres in capsules or incorporating them into tablets, degradable in the stomach. Also disclosed is a method for oral administration to a patient of said single dose. |
