| 摘要 |
This invention relates to novel methods of increasing the level of fetal hemoglobin (HbF) in a subject and methods of treating, preventing or ameliorating beta -globin or other HbF-related disorders by increasing the level of HbF in a subject in need of such treatment comprising administering one or more compounds of the formulae: (I) XCH2-CHX-CHX-C(=O)-O-Z, (II) CH3-CO-CH2-C(=O)-O-Z or (III) CH3-CH2-CO-C(=O)-O-Z, wherein X is H, or one of X only may be OH; Z is -CHR-O-C(=O)R', -CHR-O-C(=O)-O-R', or (IV); R is H, alkyl, aryl, arylalkyl; and R' is alkyl, aminoalkyl, aralkyl, aryl, alkoxy, aralkoxy and aryloxy, in which aryl by itself, and aryl in aralkyl, aralkoxy and aryloxy are each selected from the group consisting of phenyl, naphthyl, furyl, or thienyl, each of which is unsubstituted or substituted by at least one substituent selected from the group consisting of alkyl, alkoxy, or halogen; and pharmaceutically acceptable salts and prodrugs thereof.
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