| 摘要 |
<p>A novel cholecystokinin antagonist of formula (I) with good bioavailability useful as an agent in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as an antipsychotic is disclosed. Further, the compound is an antianxiety agent and antiulcer agent. It is useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compound of the invention is also useful in treating and/or preventing panic. Also disclosed is a pharmaceutical composition and processes for preparing the compound. An important feature of the instant invention is the absolute oral bioavailability of the compound.</p> |
