PERCUTANEOUSLY ABSORBABLE PLASTER COMPRISING ACID-ADDITION SALT OF MORPHINE

摘要

A percutaneously absorbable plaster composed of a support and, formed on one side thereof, a pressure-sensitive adhesive layer comprising a pressure-sensitive adhesive, a drug and a percutaneous absorption accelerator, wherein the drug is an acid-addition salt of morphine and the accelerator comprises a compound (A) having a log P value of -0.5 to 2.0 (P being the partition coefficient of an octanol/water system). The plaster enables a pharmacologically acceptable acid-addition salt of morphine to be released uniformly and stably for long, is excellent in percutaneous penetration, and can effectively be applied to patients with pain, cough, diarrhea, and so forth.