INHIBITION OF CELL PROLIFERATION BY E2F-1 ANTISENSE OLIGONUCLEOTIDES

摘要

Antisense oligonucleotides specific for the E2F-1 gene inhibit proliferation of cells. The oligonucleotides are useful in the treatment of neoplastic diseases, primarily neoplastic diseases characterized by the growth of solid tumors. The E2F-1 antisense oligonucleotides are in particular believed useful for treating those cancers characterized by the inactivation of functional retinoblastoma tumor surpressor gene expression.