| 摘要 |
<p>The present invention provides paclitaxel derivatives of formula I
<Chemistry id="chema01" num="0001"><Image id="ia01" he="51" wi="93" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
in which
<DefinitionList id="dla01"><DefinedTerm>R¹ is</DefinedTerm><DefinitionDescription>-COR<Sup>z</Sup>, in which R<Sup>z</Sup> is RR<Sup>o</Sup>N-, RHN-, RO- or R;</DefinitionDescription><DefinedTerm>R² is</DefinedTerm><DefinitionDescription>C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, or a radical of the formula -W-R<Sup>x</Sup> in which W is a bond, C₂₋₆ alkenediyl, or -(CH₂)<Sub>t</Sub>-, in which t is one to six; and R<Sup>x</Sup> is naphthyl, phenyl, or heteroaryl, and furthermore R<Sup>x</Sup> can be optionally substituted with one to three same or different C₁₋₆ alkyl, C₁₋₆ alkoxy, halogen or -CF₃ groups;</DefinitionDescription><DefinedTerm>R and R<Sup>o</Sup> are</DefinedTerm><DefinitionDescription>independently C₁₋₆ alkyl, C₂₋₆ alkenyl, C₃₋₆ cycloalkyl, C₂₋₆ alkynyl, or phenyl, optionally substituted with one to three same or different C₁₋₆ alkyl, C₁₋₆ alkoxy, halogen or -CF₃ groups.</DefinitionDescription></DefinitionList><!-- EPO <DP n="55"> --></p><p>Also provided by this invention are pharmaceutical formulations (compositions) and a method of treating mammalian tumors with a compound of formula I.</p> |
