5-Vinyl- and 5-ethinyl-quinolinone- and -naphthyridone-carboxylic acids.

摘要

Quinolone and naphthyridone derivs. of formula (I), and their hydrates, acid addn. salts, and alkali-, alkaline earth, silver and guanidinium salts, are new. R1 = 1-4C alkyl (opt. substd. by OH, halo or 1-3C alkoxy), 3-6C cycloalkyl (opt. substd. by halo or 1-3C alkyl), 2-4C alkenyl, 1-3C alkoxy, amino, 1-3C monoalkylamino, 2-6C dialkylamino, or phenyl (opt. substd. by 1-3 halo); R2 = H, 1-4C alkyl or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl; X = CH, C-halo, COMe, COCHF2, CMe or N; Z = CR4=CHR3 or C IDENTICAL CR5; R3 = H, 1-3C alkyl, 1-3C alkoxy, or 1-3C alkoxy-methyl; R4 = H or halo; R5 = H, 1-6C alkyl (opt. substd. by 1-3 halo or OH), 2-3C alkenyl, 1-3C alkoxy, 1-3C alkoxy-methyl, halo or SiMe3; R6 = H, 1-4C alkyl (opt. substd. by OH or OMe), cyclopropyl, 1-4C oxoalkyl, or 1-3C acyl; Y = NR'R"; NR'R" = pyrrolyl, imidazolyl or a specified satd. or mono-unsatd. mono-or bicyclic ring, (opt. contg. O or a second N, opt. substd.)