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发明名称 Live vaccines.
摘要 <p>The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine. In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.</p>
申请公布号 EP0400958(B1) 申请公布日期 1995.09.13
申请号 EP19900305819 申请日期 1990.05.29
申请人 THE WELLCOME FOUNDATION LIMITED;THE ROYAL SOCIETY;THE LISTER INSTITUTE OF PREVENTIVE MEDICINE;THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE 发明人 DOUGAN, GORDAN, THE WELLCOME FOUNDATION LIMITED;CHATFIELD, STEVEN NEVILLE, THE WELLCOME FOUNDATION;HIGGINS, CHRISTOPHER FRANCIS, IMPERIAL CANCER RES.;DORMAN, CHARLES JAMES, THE UNIVERSITY COURT
分类号 C12N15/09;A61K39/02;A61K39/095;A61K39/10;A61K39/102;A61K39/106;A61K39/108;A61K39/112;C12N1/21;C12N15/31;C12R1/01;C12R1/185;C12R1/21;C12R1/42;C12R1/63;(IPC1-7):A61K39/02 主分类号 C12N15/09
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