| 发明名称 |
CHEMICALLY MODIFIED PROTEIN AND PRODUCTION THEREOF |
| 摘要 |
Disclosed are chemically modified proteins having a group of the formula: <IMG> (wherein R represents a hydrogen atom or a lower alkyl, m represents a positive integer and n represents an integer of 1 to 4), the group being bonded to at least one primary amino group of the protein. The chemically modified proteins can be produced by reacting a protein with an imidoester of the formula: <IMG> (wherein R, n and m are as defined above and R' represents an ester forming group). The chemically modified proteins are useful as drugs, among others.
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| 申请公布号 |
CA1336967(C) |
申请公布日期 |
1995.09.12 |
| 申请号 |
CA19870531453 |
申请日期 |
1987.03.09 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
UENO, HAYAO;FUJINO, MASAHIKO |
| 分类号 |
A61K38/00;C07C67/00;C07C241/00;C07C251/08;C07K1/00;C07K1/107;C07K1/113;C07K14/00;C07K14/195;C07K14/41;C07K14/52;C07K14/54;C07K14/55;C07K14/555;C07K14/56;C07K14/57;C12P21/00;C12P21/02;C12R1/19;(IPC1-7):C12N9/00;A61K37/00;C07K3/08;C07K13/00;C07K15/00 |
主分类号 |
A61K38/00 |
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