发明名称 |
ANIMALS WITH TARGETED GENE DISRUPTION |
摘要 |
The invention provides transgenic non-human animals in which genes encoding colony-stimulating factors have been specifically disrupted, so that the animals do not express the respective factors. In specific embodiments the invention provides mice in which expression of GM-CSF, G-CSF and/or CSF-1 is disrupted. These animals do not produce any bioactive CSF of the respective type. They are useful as models for a variety of conditions, and particularly for testing of therapeutic methods.
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申请公布号 |
CA2184707(A1) |
申请公布日期 |
1995.09.08 |
申请号 |
CA19942184707 |
申请日期 |
1994.03.04 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
DUNN, ROGER ASHLEY;STANLEY, GUY EDOUARD;LIESCHKE, JOHN GRAHAM;GRAIL, DIANNE;FOWLER, KERRY J. |
分类号 |
A01K67/027;A61K9/12;A61K31/70;A61K38/19;C12N5/10;C12N15/18;C12N15/19;C12N15/27;(IPC1-7):C12N15/27 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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