发明名称 |
YEAST STRAINS AND MODIFIED ALBUMINS |
摘要 |
Albumin, for example human albumin, is expressed and secreted in yeast which has been mutated to lack the yeast aspartyl protease 3 (Yap3p) or its equivalent, thereby reducing the production of a 45kD albumin fragment. A further reduction is achieved by additionally deleting the Kex2p function. Alternatively, a modified albumin is prepared which is not susceptible to Yap3p cleavage, for example human albumin which is R410A, K413Q and K414Q.
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申请公布号 |
WO9523857(A1) |
申请公布日期 |
1995.09.08 |
申请号 |
WO1995GB00434 |
申请日期 |
1995.03.01 |
申请人 |
DELTA BIOTECHNOLOGY LIMITED;KERRY-WILLIAMS, SEAN, MARTIN;GILBERT, SARAH, CATHERINE |
发明人 |
KERRY-WILLIAMS, SEAN, MARTIN;GILBERT, SARAH, CATHERINE |
分类号 |
C12N15/09;A61K38/00;A61P9/00;A61P43/00;C07K14/765;C12N1/19;C12N9/60;C12N15/12;C12N15/81;C12P21/02;C12R1/865;(IPC1-7):C12N15/12;C12N1/21;A61K38/38;C12N15/11;C12N1/20 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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