ADHESIVE FREE TOPICAL PHARMACEUTICAL FORMULATIONS

摘要

An adhesive-free topical pharmaceutical formulation comprising an absorbent material wherein the absorbent material is impregnated with a pharmaceutical composition comprising a solution of a non-steroidal anti-inflammatory drug in a C2-4 alcohol. Suitably the non-steroidal antiinflammatory drug comprises ibuprofen, S(+)-ibuprofen, flurbiprofen, S(+)-flurbiprofen, R(-)-flurbiprofen, ketoprofen, S(+)-ketoprofen, piroxicam, or naproxen, including pharmaceutically acceptable salts of each and comprises 0.1-25 % by wight of the pharmaceutical composition. The C2-4 alcohol comprises 20-95 % by weight of the pharmaceutical composition. The pharmaceutical composition further comprises 0.01-90 % by weight of a co-solvent selected from propylene glycol, benzyl alcohol, isopropyl palmitate, isopropyl myristate, or polyvinylpyrrolidone. The formulation is preferably in the form of a wipe or a wrap-around. The formulations are useful for the local treatment of pain and inflammation.