发明名称 |
Vacuolating toxin-deficient (h. pylori) and related methods |
摘要 |
An isolated nucleic acid encoding the Helicobacter pylori vacuolating toxin, consisting of the nucleotides 101 through 3964 of the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:1 is provided. An isolated nucleic acid from Helicobacter pylori comprising the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:3 is provided. Isolated nucleic acids that selectively hybridize with the nucleic acids of the invention are provided. Also provided is a genetically altered mutant strain of H. pylori that does not express a functional vacuolating toxin. Purified proteins encoded by the nucleic acids of the invention are provided. A composition comprising an immunogenic amount of a protein or mutant strain of the invention in a pharmaceutically acceptable carrier is provided. A method of immunizing a subject against infection by H. pylori, comprising administering to the subject an immunogenic composition of the invention is provided. |
申请公布号 |
AU1927495(A) |
申请公布日期 |
1995.09.11 |
申请号 |
AU19950019274 |
申请日期 |
1995.02.23 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
TIMOTHY L COVER;MARTIN J. BLASER |
分类号 |
C12N15/09;A61K31/365;A61K38/00;A61K39/00;A61K39/02;A61K39/106;A61K39/395;A61P1/04;A61P31/04;C07H21/04;C07K1/20;C07K14/195;C07K14/205;C07K14/41;C07K14/435;C07K16/00;C07K16/12;C12N1/21;C12N15/31;C12P21/02;C12P21/08;C12Q1/68;C12R1/01;G01N33/531;G01N33/569 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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