| 摘要 |
PURPOSE:To obtain a medicine composition useful as a preventive and therapeutic agent for hepatitis, an endotoxin shock protecting action agent, having excellent endotoxin shock protecting action, treating action on hepatitis and inhibitory action on aggregation of blood platelet, comprising a specific pyridazinone derivative as an active ingredient. CONSTITUTION:A medicine composition comprises a compound of formula I [R<1> is a (substituted) 1-10C alkyl, a 3-6C cycloalkyl, a lower alkenyl, etc.; R<3> is H, a (substituted) lower alkyl, a lower alkyl, etc.; R<2> is H, a (substituted) lower alkyl, an aryl, etc.; A-B are (<=2 lower alkyl-or phenyl-substituted) ethylene or vinylene; D is H or a halogen; n is 1 or 2] or its salt such as 2- methylsulfonylamino-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane as an active ingredient. The compound of formula I, for example, is obtained by reacting a compound of formula II (R<4> is H or a lower alkyl) with a compound of formula III. |
