| 摘要 |
The invention comprises compounds of the general formula <FORM:1011840/C2/1> wherein A is a mono- or bicyclic ring of at least 5 carbon atoms, B is a ring of 5 or 6 carbon atoms, NRR1 is an amino group substituted on ring B in which R and R1 are hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl or substituted aralkyl, the amino group being at least beta to the spiro carbon atom, Y is at least one member on ring A selected from hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, substituted aralkyl and alkoxy, and X is at least one member on ring B selected from hydrogen, alkyl, alkenyl, aralkyl, substituted aralkyl and cycloalkyl, and acid addition salts thereof. The primary amines are prepared by standard methods, e.g. from the corresponding ketones via the oximes, and may be converted to the secondary and tertiary amines, e.g. by alkylation or via the amides. The tertiary amines may be converted to quaternary ammonium salts. The compounds of the invention have local anaesthetic, analgesic, respiratory stimulant, antibarbiturate and antinarcotic activity and may be administered peripherally or systemically in the form of pharmaceutical or veterinay preparations (e.g. aqueous solutions) containing them together with a carrier.
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