| 摘要 |
Therapeutic compounds with at least one carboxylic acid, ester or amide-substituted side chain have the formula:CORE MOIETY -(R)jwherein j is an integer from one to three. The core moiety is non-cyclic or cyclic (carbocyclic or heterocyclic). R may be selected from among hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted C(1-10) alkyl, C(2-10) alkenyl, carbocyclic or heterocyclic groups and at least one R has the formula I: wherein: one or two p are the integer one, otherwise p is two; and n is an integer from three to twenty; R1 is selected from the group consisting of substituted and unsubstituted CH2; NR3, R3 being hydrogen, substituted or unsubstituted C(1-20) alkyl, C(1-20) alkoxyl, C(2-20) alkenyl or C(1-20) hydroxyalkyl, or carbocyclic or heterocyclic group; O; -CHR4O-, R4 being substituted or unsubstituted C(1-20) alkyl, C(1-20) alkoxyl, C(2-20) alkenyl, C(1-20) hydroxyalkyl, or R2 and R4 join to form a substituted or unsubstituted heterocycle having four to seven ring atoms, the ether group -O- of -CHR4O- being a member of the heterocycle. R2 is selected from the group consisting of hydrogen; halogen; substituted or unsubstituted C(1-10) alkyl; C(1-10) alkoxyl; C(2-10) alkenyl; C(1-10) hydroxyalkyl; -A(R5)m, A being N or 0, m being one or two and R5 being hydrogen, a substituted or unsubstituted C(1-10) alkyl, C(1-10) alkoxyl, C(2-10) alkenyl or C(1-10) hydroxyalkyl), or carbocyclic or heterocyclic group. At least one of R1 is NR3, O or -CHR4O-, or R2 is -A(R5)m. The compounds and pharmaceutical compositions thereof are useful as therapies for diseases advanced via intracellular signaling through specific intracellular signaling pathways by mediating a signaling response to an external stimuli. |
