| 摘要 |
<p>This invention relates to methods of treatment of diseases and various other undesirable bodily states which involve the excessive, inappropriate, and/or prolonged activity of voltage-activated ion channels, and are ameliorated by administration of compounds which block said channels. The methods involve the administration to mammals of compounds which block one or more classes of voltage-activated sodium and/or calcium ion channels, in a manner operationally defined herein as 'use-dependent'. Specific examples of conditions treatable by compounds of the invention include but are not limited to ischemic brain disease, ischemic heart disease, epilepsy, and amyotrophic lateral sclerosis (LAS).</p> |
