发明名称 |
NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS |
摘要 |
Compounds are provided having structure (I), wherein the L groups are backbone segments, the Y and T groups are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidization step or during a coupling step.
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申请公布号 |
WO9523160(A1) |
申请公布日期 |
1995.08.31 |
申请号 |
WO1995US02267 |
申请日期 |
1995.02.23 |
申请人 |
ISIS PHARMACEUTICALS, INC.;COOK, PHILLIP, DAN;ACEVEDO, OSCAR;HEBERT, NORMAND |
发明人 |
COOK, PHILLIP, DAN;ACEVEDO, OSCAR;HEBERT, NORMAND |
分类号 |
C12N9/99;A61K31/66;A61K31/70;A61K31/7028;A61K31/7088;A61P29/00;A61P31/00;A61P43/00;C07F9/09;C07F9/24;C07H15/00;C07H21/00;C08G79/02;C08G79/04;C12Q1/68;(IPC1-7):C07H19/00;C07H19/20 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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