INJECTABLE EMULSIONS CONTAINING ANTIFUNGAL TRIAZOLE DERIVATIVES

摘要

An injectable oil-in-water emulsion composition comprises an antifungal triazole compound of formula (I) wherein Ar represents a substituted phenyl group; R1 and R2 represent, independently, a hydrogen atom or a lower alkyl group, or R1 and R2 may together form a lower alkylene group; R4 represents a hydrogen atom or an acyl group; and A represents an optionally substituted cyclic amide group bonded through a nitrogen atom, or a salt thereof. The solubility of the triazole compound having poor water-solubility and fatsolubility can remarkably be increased by dispersing in water with use of an oil component (e.g. a triglyceride of fatty acids) and an emulsifier (e.g. a phospho-lipid).