METHODS FOR IDENTIFYING INHIBITORS OF FUNGAL PATHOGENICITY

摘要

Methods of detecting inhibitors of fungal pathogenicity are disclosed. These methods are based on the discovery that pathogenicity is diminished when chitin synthase III is inhibited. The inhibitors of fungal pathogenicity are detected with mutant strains of S. cerevisiae or other mutant fungal strains, whose mutation causes diminished growth of the fungus when combined with the inhibition of chitin synthase III.