发明名称 |
Moenomycin degradation products containing hydroxylated or oxidized lateral lipid chain and moenomycin analogs, process for preparing and their use. |
摘要 |
The invention relates to MA of the formula I <IMAGE> in which R<1>, R<2>, R<4> and R<5> independently of one another are a hydroxyl group or hydrogen and R<3> is hydrogen, where the bond between the C atom carrying the substituent R<4> and the C atom carrying the substituent R<5> is a single bond, or R<1> and R<2> independently of one another are a hydroxyll group or hydrogen and R<3> is hydrogen, where the bond between the C atom carrying the substituent R<4> and the C atom carrying the substituent R<5> is a double bond, or R<1>, R<2> and R<5> independently of one another are a hydroxyl group or hydrogen and R<3> and R<4> together are an oxo group. MA is hydroxylated or oxidised in the lateral lipid chain by microorganisms of the order Cryptococcus and in this form is a starting compound for the preparation of moenomycin analogues which can be employed as medicaments. The moenomycin analogues have the following chemical structure: <IMAGE> in which R<1> to R<5> have the abovementioned meanings.h |
申请公布号 |
EP0652205(A3) |
申请公布日期 |
1995.08.30 |
申请号 |
EP19940117181 |
申请日期 |
1994.10.31 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
ARETZ, WERNER, DR.;HEDTMANN, UDO, DR. |
分类号 |
C07C59/60;C07C59/90;C07H3/06;C07H11/04;C07H13/12;C12N1/16;C12P7/42;C12R1/645 |
主分类号 |
C07C59/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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