Purine analog nucleoside and nucleotide compounds

摘要

PCT No. PCT/EP90/00650 Sec. 371 Date Feb. 21, 1992 Sec. 102(e) Date Feb. 21, 1992 PCT Filed Apr. 23, 1990 PCT Pub. No. WO91/01325 PCT Pub. Date Feb. 7, 1991.The invention concerns nucleoside derivatives of the formula I <IMAGE> (I) in which Ba signifies an indolyl (A), benzimidazolyl (B), pyrrolopyridinyl (C), imidazopyridinyl (D), triazolopyrimidinyl (E), imidazotriazinyl (F) or imidazopyrimidinyl (G) group substituted by R1, R2 and R3, in which R1, R2 and R3, which can be the same or different, signify hydrogen, halogen, a C1-C7-alkyl, C2-C7-alkenyl, hydroxy, mercapto, C1-C7-alkylthio, C1-C7-alkoxy, C2-C7-alkenyloxy, ar-C1-C5-alkyl, ar-C2-C5-alkenyl, ar-C1-C5-alkoxy, ar-C2-C5-alkenyloxy, aryloxy, nitro, amino-C1-C7-alkyl, C1-C7-alkylamino-C1-C7-alkyl, di-C1-C7-alkylamino-C1-C7-alkyl, amino, a substituted amino group -NMR4 or -N(R4)2 or an imino group -N=CH-R4, and R4 has the meaning given in the description, R5, R6, R7 and R8 each signify hydrogen or one or two of the radicals R5, R6, R7 and R8 a hydroxyl, halogen, cyano, azido or a substituted amino group -NHR4 or -N(R4)2 or R5 and R7 can together represent a further bond between C-2' and C-3' and Y represents hydrogen or a C1-C7-alkylcarbonyl, monophosphate, diphosphate or triphosphate group, whereby "aryl" signifies a phenyl or naphthyl group and "hetaryl" a furanyl, thienyl or pyridyl group, as well as their possible anomers, N7- or N9-regioisomers (purine nomenclature), tautomers and salts.