发明名称 |
20-methyl-substituted vitamin D derivatives |
摘要 |
New 20-methyl-substituted vitamin D derivatives of general formula I <IMAGE> (I) are described in which R1 means a hydrogen atom, a hydroxy group or an alkanoyloxy group with 1 to 12 carbon atoms or a benzoyloxy group, R2 means a hydrogen atom or an alkanoyl group with 1 to 12 carbon atoms or a benzoyl group and R3 means a saturated or unsaturated, straight-chain or branched hydrocarbon radical with up to 18 C atoms, which optionally contains carbocyclic structures, optionally substituted with one or more hydroxy, oxo, amino group(s) and/or one or more halogen atom(s) as well as optionally exhibits one or more oxygen, sulfur and/or nitrogen atom(s) as a bridging link or links in the hydrocarbon radical, and a process for their production. Relative to calcitriol, the new compounds exhibit a greatly improved induction of cell differentiation (HL-60) and are suitable for the production of pharmaceutical agents.
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申请公布号 |
US5446035(A) |
申请公布日期 |
1995.08.29 |
申请号 |
US19940307081 |
申请日期 |
1994.09.16 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
NEEF, GUENTER;STEINMEYER, ANDREAS;KIRSCH, GERALD;SCHWARZ, KATICA;THIEROFF-EKERDT, RUTH;WIESINGER, HERBERT;HABEREY, MARTIN |
分类号 |
A61K31/59;A61P3/02;A61P3/14;A61P17/00;A61P35/02;A61P37/00;A61P43/00;C07C401/00;(IPC1-7):C07C401/00 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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地址 |
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