ARYL AMINO THIAZOL ACETIC ACID AND PROCESS FOR PREPARING THE SAME

摘要

Arylaminothiazol acetic acid of formula (I) is perpd. by condensasion of the ketone cpd. of formula (II) and the amine cpd. of formula (III) in the mixed solvent comprising a polar solvent e.g. ethanol or methanol and water in the condition of 4-6 pH. pref. using an alkali metalic salts solution e.g. sodium hydroxide or sodium carbonate. In the formulas, R1 is H, formyl or trityl; R2 is carboxylic acid, C1-4 alkyl ester or carboxylic acid chloride; R3 and R4 are H, acetyl or para- methoxy benzyl; X and Y are H or halogen.