| 发明名称 |
Process for synthesis of FK-506 and tricarbonyl intermediates |
| 摘要 |
A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.
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| 申请公布号 |
US5446158(A) |
申请公布日期 |
1995.08.29 |
| 申请号 |
US19900596847 |
申请日期 |
1990.10.12 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
JONES, TODD K.;MILLS, SANDER G.;ASKIN, DAVID;REAMER, ROBERT A.;DESMOND, RICHARD;TSCHAEN, DAVID M.;VOLANTE, RALPH P.;SHINKAI, ICHIRO |
| 分类号 |
C07D211/60;C07B53/00;C07C69/716;C07C231/12;C07C235/12;C07C235/72;C07C323/52;C07C323/60;C07D207/16;C07D263/26;C07D273/01;C07D339/08;C07D405/06;C07D498/08;C07D498/18;C07F7/18;(IPC1-7):C07F7/18 |
主分类号 |
C07D211/60 |
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