| 摘要 |
The present invention provides a series of non-toxic compounds which function to inhibit the activity of S-1-P aldolase in respect to its cleavage of S-1-P. These inhibitors are described by the compounds of formula I <IMAGE> (I) wherein R is a radical containing 1 to 15 carbon atoms, a halogen, or hydrocarbon, R' is an organic radical or hydrogen, and R'' is -NH3+ or -NH-NH +, with the proviso that, when R is CH3(CH)12(CH=CH) and R' is hydrogen, R'' is -NH-NH3+. A method for preparing such compounds, which may generally be described as 1-phosphate derivatives of compounds which include a 2-amino-1,3-alcohol radical is also disclosed. |
