| 摘要 |
A novel (fused) benz(thio)amide of the general formula: <IMAGE> (I) or a non-toxic salt thereof, wherein A represents a single bond or a group as defined in the specification; B represents (i) a substituted or unsubstituted carbocyclic ring of 4 to 8 members being unreplaced or optionally having one, two or three carbon atom(s) replaced by oxygen, nitrogen and/or sulfur atom(s); or (ii) a divalent group of formula: <IMAGE> T represents oxygen or sulfur; R1 represents a group of general formula: <IMAGE> (i) <IMAGE> (ii) <IMAGE> (iii) or (iv) a straight or branched alkyl, alkenyl or alkynyl group of from 1 to 20 carbon atom(s); R2 represents hydrogen or a straight or branched alkyl group of from 1 to 6 carbon atom(s); R'represents hydrogen, a halogen atom, a hydroxy group, a nitro group or a group -COOR7; R4 represents: (i) when B represents a closed ring, a group of the general formula: U(CH2)nCOOR8 <IMAGE> (CH2)pCOOR8 or <IMAGE> wherein U represents an oxygen atom or a sulfur atom; or (ii) when B represents a divalent group, a group of the general formula: (CH2)pCOOR8 or <IMAGE> wherein R5, R6, R7, R8, n, m, p and q are as defined in the specification, and excluding certain compounds as defined in the specification, depending on whether A represents a single bond or a group. The compounds are useful for the prevention and/or treatment of diseases induced by leukotrienes, 5 alpha -reductase, phospholipase and aldose reductase in mammals, especially human beings.
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