发明名称 |
2-(4-METHOXYPHENOXY)-3-PYRIDINEAMINE, ITS PREPARATION AND ITS USE AS ANTI-INFLAMMATORY AGENT |
摘要 |
The product 3-amino-2-(4-methoxyphenoxy)pyridine and its pharmaceutically suitable salts, in particular the hydrochloride, are novel products which are prepared by catalytic hydrogenation of 2-(4-methoxyphenoxy)-3-nitropyridine, optionally in the presence of the acid corresponding to the salt. Its pharmaceutical compositions containing sufficient amounts of suitable auxiliaries for its topical administration prove particularly useful in therapy for the treatment of inflammatory skin diseases. The tests for dermatological action with the aid of TPA-induced mouse ear oedema and of carragenan-induced rat paw oedema show that the product is very much more active by the topical route than ibuprofen and nimesulide, two known anti-inflammatory active compounds, of which the first is very widely known and the second structurally related.
|
申请公布号 |
WO9522528(A1) |
申请公布日期 |
1995.08.24 |
申请号 |
WO1995EP00525 |
申请日期 |
1995.02.13 |
申请人 |
HANDFORTH INVESTMENTS LTD.;ALDOMA, GUSTAVO, ENRIQUE;PIATTI, SUSANA, ELIDA |
发明人 |
ALDOMA, GUSTAVO, ENRIQUE;PIATTI, SUSANA, ELIDA |
分类号 |
C07D213/643;A61K31/44;A61K31/4425;A61P17/00;A61P29/00;C07D213/73;(IPC1-7):C07D213/73 |
主分类号 |
C07D213/643 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|