发明名称 |
Method of diagnosing cancer precancerous state or susceptibility to other forms of diseases by analysis or IRF-1-specific RNA in biopsy samples |
摘要 |
The present invention relates to a method of diagnosing cancer, precancerous state, and susceptibility to other forms of diseases, by use of a molecular marker, interferon-regulatory factor-1 (IRF-1). The method is characterized in that IRF-1-specific RNA is analysed in a sample obtained from blood or other biopsy material, preferably by reverse transcription/polymerase chain reaction. The invention is based on the unexpected finding that a novel mechanism of inactivation of the tumor suppressor gene IRF-1 plays a crucial role e.g. in hematopoietic malignancies. An unusual exon skipping leads to RNA molecules which lack exon 2 or exons 2 and 3. The relative amounts of full-length RNA and shortened RNA molecules are significantly different in samples obtained from tumor patients as compared to healthy donors. <IMAGE> |
申请公布号 |
ZA9501526(B) |
申请公布日期 |
1995.08.24 |
申请号 |
ZA19950001526 |
申请日期 |
1995.02.23 |
申请人 |
BOEHRINGER INGELMEIM INTERNATIONAL GMBH. |
发明人 |
TADATSUGU TANIGUCHI;HISASHI HARADA |
分类号 |
C12N15/09;A61K38/00;A61K49/00;C07H21/02;C07K14/47;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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