| 摘要 |
<p>Therapeutic compounds with at least one carboxylic, acid, ester or amide-substituted moiety have the formula: TERMINAL MOIETY-(R)j. In the formula, j is an integer from one to three, the terminal moiety is an aliphatic chemical moiety or a ring system and R is selected from among hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted C(1-10)alkyl, C(2-10)alkenyl, carbocyclic or heterocyclic groups and at least one R having formula (I). In formula (I), one or two p are the integer one, otherwise p is two and n is an integer from three to twenty, preferably seven to sixteen or nine to fourteen. The compounds and pharmaceutical compositions thereof are useful as therapies for diseases advanced via intracellular signaling through specific intracellular signaling pathways by mediating a signaling response to an external stimulus.</p> |
