| 发明名称 | 取代的杂环羧酰胺、它们的制备及作为药物的应用 | ||
| 摘要 | 本发明涉及式I化合物，其制备方法和作为药物的应用。这些化合物特别可用于抑制胶原蛋白生物合成，和用作脯氨酰基羟化酶抑制剂及纤维变性抑制剂。 | ||
| 申请公布号 | CN1107145A | 申请公布日期 | 1995.08.23 |
| 申请号 | CN94117623.1 | 申请日期 | 1994.11.02 |
| 申请人 | 赫彻斯特股份公司 | 发明人 | K·韦德曼;K-H·巴林豪斯;G·查奇克;M·比克尔 |
| 分类号 | C07D213/89;C07D237/10;A61K31/44;A61K31/495 | 主分类号 | C07D213/89 |
| 代理机构 | 中国国际贸易促进委员会专利商标事务所 | 代理人 | 侯天军 |
| 主权项 | 1、一种式Ⅰ所示的化合物及其药理活性盐 <img file="941176231_IMG2.GIF" wi="1063" he="556" />其中： Q是O、S、NR’或一个键， X是O或S， Y是C-R<sup>3</sup>，或者如果R<sup>1</sup>和R<sup>2</sup>成环，Y是N或CR<sup>3</sup>， m是0或1， A是(C<sub>1</sub>-C<sub>4</sub>)亚烷基，它可非强制性地被一种或两种下列取代基取代：卤，氰基，硝基，三氟甲基，(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>1</sub>-C<sub>6</sub>)羟烷基，(C<sub>1</sub>-C<sub>6</sub>)烷氧基，-O-[CH<sub>2</sub>]<sub>x</sub>-C<sub>f</sub>H<sub>(2f+1-g)</sub>Hal<sub>g</sub>、特别是(C<sub>1</sub>-C<sub>8</sub>)氟代烷氧基、(C<sub>1</sub>-C<sub>8</sub>)氟代链烯基氧基、(C<sub>1</sub>-C<sub>8</sub>)氟代链炔基氧基、-OCF<sub>2</sub>Cl或-O-CF<sub>2</sub>-CHFCl，(C<sub>1</sub>-C<sub>6</sub>)烷硫基，(C<sub>1</sub>-C<sub>6</sub>)烷基亚磺酰基，(C<sub>1</sub>-C<sub>6</sub>)烷基磺酰基，(C<sub>1</sub>-C<sub>6</sub>)烷基羰基，(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，氨基甲酰基，N-(C<sub>1</sub>-C<sub>4</sub>)烷基氨基甲酰基、N，N-二(C<sub>1</sub>-C<sub>4</sub>)烷基氨基甲酰基，(C<sub>1</sub>-C<sub>6</sub>)烷基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基，苯基，苄基，苯氧基，苄氧基，苯胺基，N-甲基苯胺基，苯硫基，苯磺酰基，苯亚磺酰基，氨磺酰基，N-(C<sub>1</sub>-C<sub>4</sub>)烷基氨磺酰基，或N，N-二(C<sub>1</sub>-C<sub>4</sub>)烷基氨磺酰基；该亚烷基或者被取代的(C<sub>6</sub>-C<sub>12</sub>)芳氧基、(C<sub>7</sub>-C<sub>11</sub>)芳烷氧基、(C<sub>6</sub>-C<sub>12</sub>)芳基或(C<sub>7</sub>-C<sub>11</sub>)芳烷基取代，上述取代的基团可在芳核上带有1，2，3，4或5个相同或不同的下列取代基：卤，氰基，硝基，三氟甲基，(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>1</sub>-C<sub>6</sub>)烷氧基，-O-[CH<sub>2</sub>]<sub>x</sub>-C<sub>f</sub>H<sub>(2f+1-g)</sub>Hal<sub>g</sub>，-O-CF<sub>2</sub>Cl，-O-CF<sub>2</sub>-CHFC，(C<sub>1</sub>-C<sub>6</sub>)烷硫基，(C<sub>1</sub>-C<sub>6</sub>)烷基亚磺酰基，(C<sub>1</sub>-C<sub>6</sub>)烷基磺酰基，(C<sub>1</sub>-C<sub>6</sub>)烷基羰基，(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，氨基甲酰基，N-(C<sub>1</sub>-C<sub>4</sub>)烷基氨基甲酰基，N，N-二(C<sub>1</sub>-C<sub>4</sub>)烷基氨基甲酰基，(C<sub>1</sub>-C<sub>6</sub>)烷基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基，氨磺酰基，N-(C<sub>1</sub>-C<sub>4</sub>)烷基氨磺酰基或N，N-二(C<sub>1</sub>-C<sub>4</sub>)烷基氨磺酰基；该亚烷基或者被α-氨基酸的α-碳原子上的取代基R<sup>5</sup>取代，可以使用天然L-氨基酸及其D-异构体。 B是酸性基，选自-CO<sub>2</sub>H、-CONHCOR”’、-CONHSOR”’、-CONHSO<sub>2</sub>R”’、-NHSO<sub>2</sub>CF<sub>3</sub>、四唑基、咪唑基、或3-羟基异恶唑基，其中的R”’是芳基、杂芳基、(C<sub>3</sub>-C<sub>7</sub>)环烷基或(C<sub>1</sub>-C<sub>4</sub>)烷基，它们可非强制性地被(C<sub>6</sub>-C<sub>12</sub>)芳基、杂芳基、OH、SH、(C<sub>1</sub>-C<sub>4</sub>)烷基、(C<sub>1</sub>-C<sub>4</sub>)烷氧基、(C<sub>1</sub>-C<sub>4</sub>)硫代烷基、(C<sub>1</sub>-C<sub>4</sub>)烷基亚磺酰基、(C<sub>1</sub>-C<sub>4</sub>)烷基磺酰基、CF<sub>3</sub>、Cl、Br、F、I、NO<sub>2</sub>、-COOH、(C<sub>2</sub>-C<sub>5</sub>)烷氧基羰基、NH<sub>2</sub>、单(C<sub>1</sub>-C<sub>4</sub>烷基)氨基、二(C<sub>1</sub>-C<sub>4</sub>烷基)氨基或(C<sub>1</sub>-C<sub>4</sub>)全氟烷基单取代， R<sup>1</sup>、R<sup>2</sup>和R<sup>3</sup>可相同或不同，表示：氢，羟基，卤，氰基，三氟甲基，硝基，羧基，(C<sub>1</sub>-C<sub>20</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氧基-(C<sub>1</sub>-C<sub>2</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>8</sub>)烷基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基，(C<sub>6</sub>-C<sub>12</sub>)芳基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基，(C<sub>7</sub>-C<sub>16</sub>)芳基链烯基，(C<sub>7</sub>-C<sub>16</sub>)芳基链炔基，(C<sub>2</sub>-C<sub>20</sub>)链烯基，(C<sub>2</sub>-C<sub>20</sub>)链炔基，(C<sub>1</sub>-C<sub>20</sub>)烷氧基，(C<sub>2</sub>-C<sub>20</sub>)链烯基氧基，(C<sub>2</sub>-C<sub>20</sub>)链炔基氧基，视黄基氧基，(C<sub>1</sub>-C<sub>20</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>1</sub>-C<sub>6</sub>)羟烷基，(C<sub>6</sub>-C<sub>16</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>7</sub>-C<sub>12</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>2</sub>-C<sub>20</sub>)链烯基氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>2</sub>-C<sub>20</sub>)链炔基氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，视黄基氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，-O-[CH<sub>2</sub>-]<sub>x</sub>-C<sub>f</sub>H<sub>(2f+1-g)</sub>Fg，-OCF<sub>2</sub>Cl，-OCF<sub>2</sub>-CHFCl；(C<sub>1</sub>-C<sub>20</sub>)烷基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基羰基，肉桂酰基，(C<sub>2</sub>-C<sub>20</sub>)链烯基羰基，(C<sub>2</sub>-C<sub>20</sub>)链炔基羰基，(C<sub>1</sub>-C<sub>20</sub>)烷氧基羰基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基羰基，(C<sub>2</sub>-C<sub>20</sub>)链烯基氧基羰基，视黄基氧基羰基，(C<sub>2</sub>-C<sub>20</sub>)链炔基氧基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基；(C<sub>1</sub>-C<sub>12</sub>)烷基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基羰基氧基，(C<sub>6</sub>-C<sub>12</sub>)芳基羰基氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基羰基氧基，肉桂酰氧基，(C<sub>2</sub>-C<sub>12</sub>)链烯基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链炔基羰基氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基氧基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基羰基氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链烯基氧基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链炔基氧基羰基氧基；氨基甲酰基，N-(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰基，N，N-二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰基，N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N，N-二(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N-((C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>6</sub>)烷基-N-((C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷基)氨基甲酰基，N-(+)-脱氢枞酸基氨基甲酰基，N-(C<sub>1</sub>-C<sub>6</sub>)烷基-N-(+)-脱氢枞酸基氨基甲酰基，N-(C<sub>1</sub>-C<sub>12</sub>)芳基氨基甲酰基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>16</sub>)芳基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>7</sub>-C<sub>16</sub>)-芳烷基氨基甲酰基，N-((C<sub>1</sub>-C<sub>18</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-((C<sub>6</sub>-C<sub>16</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，或者CON(CH<sub>2</sub>)h，其中的CH<sub>2</sub>基可被O、S、N-(C<sub>1</sub>-C<sub>8</sub>)烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>4</sub>)烷基亚氨基、N-(C<sub>6</sub>-C<sub>12</sub>)芳基亚氨基、N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚氨基或N-(C<sub>1</sub>-C<sub>4</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基亚氨基取代，且h是3至7； 或者R<sup>1</sup>、R<sup>2</sup>或R<sup>3</sup>表示式Ⅱ所示氨基甲酰基 <img file="941176231_IMG3.GIF" wi="1144" he="475" />其中： R<sup>x</sup>是包括L-和D-氨基酸的α-氨基酸的取代基， S是1，2，3，4或5，和 T是OH，OR或NR<sup>*</sup>R<sup>**</sup>，其中： R<sup>*</sup>、R<sup>**</sup>和R<sup>***</sup>可相同或不同，表示氢、(C<sub>6</sub>-C<sub>12</sub>)芳基、(C<sub>7</sub>-C<sub>11</sub>)芳烷基、(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>3</sub>-C<sub>8</sub>)环烷基、(+)-脱氢枞酸基、(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>7</sub>-C<sub>12</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>1</sub>-C<sub>10</sub>)烷酰基、取代或未取代的(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基或者取代或未取代的(C<sub>6</sub>-C<sub>12</sub>)芳酰基，或者 R<sup>*</sup>与R<sup>**</sup>一起形成-[CH<sub>2</sub>]h，其中的CH<sub>2</sub>基团可以被O、S、SO、SO<sub>2</sub>、N-酰氨基、N-(C<sub>1</sub>-C<sub>10</sub>)烷氧基羰基亚氨基、N-(C<sub>1</sub>-C<sub>8</sub>)烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>4</sub>)烷基亚氨基、N-(C<sub>6</sub>-C<sub>12</sub>)芳基亚氨基、N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚氨基或N-(C<sub>1</sub>-C<sub>4</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基亚氨基代替，并且h是3至7； 或者R<sup>1</sup>、R<sup>2</sup>或R<sup>3</sup>表示：氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰氧基，N，N-二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰氧基，N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰氧基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基甲酰氧基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基甲酰氧基，N-((C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基；氨基，(C<sub>1</sub>-C<sub>12</sub>)烷基氨基，二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基，(C<sub>3</sub>-C<sub>12</sub>)链烯基氨基，(C<sub>3</sub>-C<sub>12</sub>)链炔基氨基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基，N-(C<sub>7</sub>-C<sub>11</sub>)芳烷基氨基，N-烷基-芳烷基氨基，N-烷基-芳基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基；(C<sub>1</sub>-C<sub>12</sub>)烷酰基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基氨基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基氨基，(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>7</sub>-C<sub>11</sub>)芳烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基；(C<sub>1</sub>-C<sub>12</sub>)烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，N，N-二(C<sub>1</sub>-C<sub>10</sub>)烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，(C<sub>1</sub>-C<sub>20</sub>)烷硫基，(C<sub>1</sub>-C<sub>20</sub>)烷基亚磺酰基，(C<sub>1</sub>-C<sub>20</sub>)烷基磺酰基，(C<sub>6</sub>-C<sub>12</sub>)芳硫基，(C<sub>6</sub>-C<sub>12</sub>)芳基亚磺酰基，(C<sub>6</sub>-C<sub>12</sub>)芳基磺酰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷硫基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚磺酰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基磺酰基，(C<sub>1</sub>-C<sub>12</sub>)烷硫基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>1</sub>-C<sub>12</sub>)烷基亚磺酰基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>1</sub>-C<sub>12</sub>)烷基磺酰基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳硫基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳基亚磺酰基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳基磺酰基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷硫基(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚磺酰基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基磺酰基-(C<sub>1</sub>-C<sub>6</sub>)烷基；氨磺酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨磺酰基，N，N-二(C<sub>1</sub>-C<sub>10</sub>)烷基氨磺酰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨磺酰基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨磺酰基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨磺酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨磺酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨磺酰基，(C<sub>1</sub>-C<sub>10</sub>)烷基磺酰氨基，N-((C<sub>1</sub>-C<sub>10</sub>)烷基)-(C<sub>1</sub>-C<sub>10</sub>)烷基磺酰氨基，(C<sub>7</sub>-C<sub>16</sub>)-芳烷基磺酰氨基或N-((C<sub>1</sub>-C<sub>10</sub>)烷基-(C<sub>7</sub>-C<sub>16</sub>)芳烷基磺酰氨基； 其中取代基R<sub>1</sub>、R<sub>2</sub>和R<sub>3</sub>含有芳基的，可在其芳基上带有1至5个相同或不同的选自下列的基团：羟基，卤，氰基，三氟甲基，硝基，羧基，(C<sub>1</sub>-C<sub>16</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>8</sub>)烷基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基，(C<sub>6</sub>-C<sub>12</sub>)芳基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基，(C<sub>2</sub>-C<sub>16</sub>)链烯基，(C<sub>2</sub>-C<sub>12</sub>)链炔基，(C<sub>1</sub>-C<sub>16</sub>)烷氧基，(C<sub>1</sub>-C<sub>16</sub>)链烯基氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>1</sub>-C<sub>8</sub>)羟烷基，(C<sub>6</sub>-C<sub>16</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>7</sub>-C<sub>12</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，-O-[CH<sub>2</sub>]<sub>x</sub>-C<sub>f</sub>H<sub>(2f+1-g)</sub>Fg，-OCF<sub>2</sub>Cl，-OCF<sub>2</sub>-CHFCl；(C<sub>1</sub>-C<sub>12</sub>)烷基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基羰基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基羰基，(C<sub>2</sub>-C<sub>12</sub>)链烯基氧基羰基，(C<sub>2</sub>-C<sub>12</sub>)链炔基氧基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基；(C<sub>1</sub>-C<sub>12</sub>)烷基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基羰基氧基，(C<sub>6</sub>-C<sub>12</sub>)芳基羰基氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基羰基氧基，肉桂酰氧基，(C<sub>2</sub>-C<sub>12</sub>)链烯基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链炔基羰基氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基氧基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基羰基氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链烯基氧基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链炔基氧基羰基氧基；氨基甲酰基，N-(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰基，N，N-二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰基，N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N，N-二(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N-((C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>6</sub>)烷基-N-((C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷基)氨基甲酰基，N-(+)-脱氢枞酸基氨基甲酰基，N-(C<sub>1</sub>-C<sub>6</sub>)烷基-N-(+)-脱氢枞酸基氨基甲酰基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基甲酰基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>16</sub>)芳基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)-N-(C<sub>7</sub>-C<sub>16</sub>)-芳烷基氨基甲酰基，N-((C<sub>1</sub>-C<sub>16</sub>)烷氧基-(C<sub>1</sub>- C<sub>10</sub>)烷基)氨基甲酰基，N-((C<sub>6</sub>-C<sub>16</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，或者CON(CH<sub>2</sub>)h，其中的CH<sub>2</sub>基团可被O、S、N-(C<sub>1</sub>-C<sub>8</sub>)烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>4</sub>)烷基亚氨基、N-(C<sub>6</sub>-C<sub>12</sub>)芳基亚氨基、N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚氨基或N-(C<sub>1</sub>-C<sub>4</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基亚胺基代替，且h是3至7；氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰氧基，N，N-二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰氧基，N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰氧基，N-(C<sub>6</sub>-C<sub>16</sub>)芳基氨基甲酰氧基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基甲酰氧基，N-((C<sub>6</sub>-C<sub>12</sub>)芳氧烷-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氧基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基；氨基，(C<sub>1</sub>-C<sub>12</sub>)烷基氨基，二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基，(C<sub>3</sub>-C<sub>12</sub>)链烯基氨基，(C<sub>3</sub>-C<sub>12</sub>)链炔基氨基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基，N-(C<sub>7</sub>-C<sub>11</sub>)芳烷基氨基，N-烷基-芳烷基氨基，N-烷基-芳基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基；(C<sub>1</sub>-C<sub>12</sub>)烷酰基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基氨基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基氨基，(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>7</sub>-C<sub>11</sub>)芳烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基；(C<sub>1</sub>-C<sub>12</sub>)烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，N，N-二(C<sub>1</sub>-C<sub>10</sub>)烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基；(C<sub>1</sub>-C<sub>12</sub>)烷硫基，(C<sub>1</sub>-C<sub>12</sub>)烷基亚磺酰基，(C<sub>1</sub>-C<sub>12</sub>)烷基磺酰基，(C<sub>6</sub>-C<sub>16</sub>)芳硫基，(C<sub>6</sub>-C<sub>16</sub>)芳基亚磺酰基，(C<sub>6</sub>-C<sub>16</sub>)芳基磺酰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷硫基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚磺酰基或(C<sub>7</sub>-C<sub>16</sub>)芳烷基磺酰基， R<sup>1</sup>和R<sup>2</sup>或者R<sup>2</sup>和R<sup>3</sup>形成链[CH<sub>2</sub>]<sub>o</sub>，饱和的或含有C=C双键不饱和链中的一个或两个CH<sub>2</sub>基可非强制地被O、S、SO、SO<sub>2</sub>或NR’代替，且O是3，4或5，和 R’是氢、(C<sub>6</sub>-C<sub>12</sub>)芳基、(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>7</sub>-C<sub>12</sub>)芳烷基氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>1</sub>-C<sub>10</sub>)烷酰基、取代或未取代的(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基或者取代或未取代的(C<sub>6</sub>-C<sub>12</sub>)芳酰基， 其中，取代基R<sup>1</sup>和R<sup>2</sup>或R<sup>2</sup>和R<sup>3</sup>与带有它们的吡啶或哒嗪一起优选形成5，6，7，8-四氢异喹啉环，5，6，7，8-四氢喹啉环或5，6，7，8-四氢肉啉环，或者 R<sup>1</sup>和R<sup>2</sup>或R<sup>2</sup>和R<sup>3</sup>形成碳环的或杂环的5-或6-员芳香环， 其中，取代基R<sup>1</sup>和R<sup>2</sup>或R<sup>2</sup>和R<sup>3</sup>与带有它们的吡啶或哒嗪一起优选形成下列取代或未取代的杂环体系： 噻吩并吡啶， 呋喃并吡啶， 吡啶并吡啶， 嘧啶并吡啶， 咪唑并吡啶， 噻唑并吡啶， 噁唑并吡啶， 喹啉，异喹啉和肉啉， 其中，喹啉、异喹啉或肉啉优选符合下式1a、1b和1c <img file="941176231_IMG4.GIF" wi="1513" he="1563" />上式中的取代基R<sup>11</sup>至R<sup>22</sup>相互独立地同R<sup>1</sup>、R<sup>2</sup>和R<sup>3</sup>的定义， 如果Q是一个键，则R<sup>4</sup>是卤、氰基或三氟甲基， 或者如果Q是O、S或NR’，则R<sup>4</sup>是支链或直链(C<sub>1</sub>-C<sub>20</sub>)烃基、式[CH<sub>2</sub>]<sub>x</sub>-C<sub>f</sub>H<sub>(2f+1-g)</sub>Fg所示的未取代饱和氟代烷基、(C<sub>6</sub>-C<sub>16</sub>)芳基、(C<sub>7</sub>-C<sub>16</sub>)芳烷基、杂芳基或杂芳烷基，其中，上述基团被一个或多个选自下列的基团取代： 羟基，卤，氰基，三氟甲基，硝基，羧基，(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>8</sub>)烷基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基，(C<sub>6</sub>-C<sub>12</sub>)芳基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基，(C<sub>2</sub>-C<sub>12</sub>)链烯基，(C<sub>2</sub>-C<sub>12</sub>)链炔基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>1</sub>-C<sub>8</sub>)羟烷基，(C<sub>6</sub>-C<sub>16</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>7</sub>-C<sub>12</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，-O-[CH<sub>2</sub>-]<sub>x</sub>-C<sub>f</sub>H<sub>(2f+1-g)</sub>Fg，-OCF<sub>2</sub>Cl，-OCF<sub>2</sub>-CHFCl；(C<sub>1</sub>-C<sub>12</sub>)烷基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基羰基，肉桂酰基，(C<sub>2</sub>-C<sub>12</sub>)链烯基羰基，(C<sub>2</sub>-C<sub>12</sub>)链炔基羰基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基羰基，(C<sub>2</sub>-C<sub>12</sub>)链烯基氧基羰基，(C<sub>2</sub>-C<sub>12</sub>)链炔基氧基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基；(C<sub>1</sub>-C<sub>12</sub>)烷基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基羰基氧基，(C<sub>6</sub>-C<sub>12</sub>)芳基羰基氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基羰基氧基，肉桂酰氧基，(C<sub>2</sub>-C<sub>12</sub>)链烯基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链炔基羰基氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基氧基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基羰基氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链烯基氧基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链炔基氧基羰基氧基；氨基甲酰基，N-(C<sub>1</sub>-C<sub>12</sub>)烷基氨甲酰基，N，N-二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰基，N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N，N-二(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N-((C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>6</sub>)烷基-N-((C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷基)氨基甲酰基，N-(+)-脱氢枞酸基氨基甲酰基，N-(C<sub>1</sub>-C<sub>6</sub>)烷基-N-(+)-脱氢枞酸基氨基甲酰基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基甲酰基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>16</sub>)芳基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰基，N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-((C<sub>6</sub>-C<sub>16</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，或者CON(CH<sub>2</sub>)h，其中的CH<sub>2</sub>基可被O、S、N-(C<sub>1</sub>-C<sub>8</sub>)烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>4</sub>)烷基亚氨基、N-(C<sub>6</sub>-C<sub>12</sub>)芳基亚氨基、N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚氨基或N-(C<sub>1</sub>-C<sub>4</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基亚氨基代替，且h是3至7；或者被式Ⅱ所示氨基甲酰基取代 <img file="941176231_IMG5.GIF" wi="1319" he="469" />其中： R<sup>x</sup>是包括L-和D-氨基酸的α-氨基酸的取代基， S是1，2，3，4或5，和 T是OH，OR或NR<sup>*</sup>R<sup>**</sup>，其中： R<sup>*</sup>、R<sup>**</sup>和R<sup>***</sup>可相同或不同，表示氢、(C<sub>6</sub>-C<sub>12</sub>)芳基、(C<sub>7</sub>-C<sub>11</sub>)芳烷基、(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>3</sub>-C<sub>8</sub>)环烷基、(+)-脱氢枞酸基、(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>7</sub>-C<sub>12</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>1</sub>-C<sub>10</sub>)烷酰基、取代或未取代的(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基或者取代或未取代的(C<sub>6</sub>-C<sub>12</sub>)芳酰基，或者 R<sup>*</sup>与R<sup>**</sup>一起形成-[CH<sub>2</sub>]h，其中的CH<sub>2</sub>基团可以被O、S、SO、SO<sub>2</sub>、N-酰氨基、N-(C<sub>1</sub>-C<sub>10</sub>)烷氧基羰基亚氨基、N-(C<sub>1</sub>-C<sub>8</sub>)烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>4</sub>)烷基亚氨基、N-(C<sub>6</sub>-C<sub>12</sub>)芳基亚氨基、N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚氨基或N-(C<sub>1</sub>-C<sub>4</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基亚氨基取代，并且h是3至7；氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰氧基，N，N-二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰氧基，N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰氧基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基甲酰氧基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基甲酰氧基，N-((C<sub>6</sub>-C<sub>12</sub>)芳氧烷-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基；氨基，(C<sub>1</sub>-C<sub>12</sub>)烷基氨基，二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基，(C<sub>3</sub>-C<sub>12</sub>)链烯基氨基，(C<sub>3</sub>-C<sub>12</sub>)链炔基氨基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基，N-(C<sub>7</sub>-C<sub>11</sub>)芳烷基氨基，N-烷基-芳烷基氨基，N-烷基-芳基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基；(C<sub>1</sub>-C<sub>12</sub>)烷酰基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基氨基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基氨基，(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>7</sub>-C<sub>11</sub>)芳烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基；(C<sub>1</sub>-C<sub>12</sub>)烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，N，N-二(C<sub>1</sub>-C<sub>10</sub>)烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基；(C<sub>1</sub>-C<sub>12</sub>)烷硫基，(C<sub>1</sub>-C<sub>12</sub>)烷基亚磺酰基，(C<sub>1</sub>-C<sub>12</sub>)烷基磺酰基，(C<sub>6</sub>-C<sub>12</sub>)芳硫基，(C<sub>6</sub>-C<sub>12</sub>)芳基亚磺酰基，(C<sub>6</sub>-C<sub>12</sub>)芳基磺酰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷硫基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚磺酰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基磺酰基；氨磺酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨磺酰基，N，N-二(C<sub>1</sub>-C<sub>10</sub>)烷基氨磺酰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨磺酰基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨磺酰基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨磺酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨磺酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨磺酰基，(C<sub>1</sub>-C<sub>10</sub>)烷基磺酰氨基，N-((C<sub>1</sub>-C<sub>10</sub>)烷基)-(C<sub>1</sub>-C<sub>10</sub>)烷基磺酰氨基，(C<sub>7</sub>-C<sub>16</sub>)-芳烷基磺酰氨基或N-((C<sub>1</sub>-C<sub>10</sub>)烷基-(C<sub>7</sub>-C<sub>16</sub>)芳烷基磺酰氨基；其中，上述取代基中含有芳核的，可在其芳基上带有1至5个相同或不同的选自下列的基团：羟基，卤，氰基，三氟甲基，硝基，羧基，(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>8</sub>)烷基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基，(C<sub>6</sub>-C<sub>12</sub>)芳基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基，(C<sub>2</sub>-C<sub>12</sub>)链烯基，(C<sub>2</sub>-C<sub>12</sub>)链炔基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基，(C<sub>1</sub>-C<sub>8</sub>)羟烷基，(C<sub>6</sub>-C<sub>16</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，(C<sub>7</sub>-C<sub>12</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基，-O-[CH<sub>2</sub>-]<sub>x</sub>-C<sub>f</sub>H<sub>(2f+1-g)</sub>Fg，-OCF<sub>2</sub>Cl，-OCF<sub>2</sub>-CHFCl；(C<sub>1</sub>-C<sub>12</sub>)烷基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基羰基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基羰基，(C<sub>2</sub>-C<sub>12</sub>)链烯基氧基羰基，(C<sub>2</sub>-C<sub>12</sub>)链炔基氧基羰基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷氧基羰基；(C<sub>1</sub>-C<sub>12</sub>)烷基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷基羰基氧基，(C<sub>6</sub>-C<sub>12</sub>)芳基羰基氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基羰基氧基，肉桂酰氧基，(C<sub>2</sub>-C<sub>12</sub>)链烯基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链炔基羰基氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基氧基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-(C<sub>1</sub>-C<sub>12</sub>)烷氧基羰基氧基，(C<sub>6</sub>-C<sub>12</sub>)芳氧基羰基氧基，(C<sub>7</sub>-C<sub>16</sub>)芳烷氧基羰基氧基，(C<sub>3</sub>-C<sub>8</sub>)环烷氧基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链烯基氧基羰基氧基，(C<sub>2</sub>-C<sub>12</sub>)链炔基氧基羰基氧基；氨基甲酰基，N-(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰基，N，N-二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰基，N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N，N-二(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰基，N-((C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>6</sub>)烷基-N-((C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>6</sub>)烷基)氨基甲酰基，M-(+)-脱氢枞酸基氨基甲酰基，N-(C<sub>1</sub>-C<sub>6</sub>)烷基-N-(+)-脱氢枞酸基氨基甲酰基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基甲酰基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>16</sub>)芳基氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>7</sub>-C<sub>16</sub>)-芳烷基氨基甲酰基，N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-((C<sub>6</sub>-C<sub>16</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰基，或者CON(CH<sub>2</sub>)h，其中的CH<sub>2</sub>基可被O、S、N-(C<sub>1</sub>-C<sub>8</sub>)烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基亚氨基、N-(C<sub>3</sub>-C<sub>8</sub>)环烷基-(C<sub>1</sub>-C<sub>4</sub>)烷基亚氨基、N-(C<sub>6</sub>-C<sub>12</sub>)芳基亚氨基、N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚氨基或N-(C<sub>1</sub>-C<sub>4</sub>)烷氧基-(C<sub>1</sub>-C<sub>6</sub>)烷基亚氨基取代，且h是3至7；氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰氧基，N，N-二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基甲酰氧基，N-(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基甲酰氧基，N-(C<sub>6</sub>-C<sub>16</sub>)芳基氨基甲酰氧基，N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-(C<sub>7</sub>-C<sub>16</sub>)芳烷基氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基甲酰氧基，N-((C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>1</sub>-C<sub>10</sub>)烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基，N-(C <sub>1 -C </sub>10 )烷基-N-((C<sub> 6 -C </sub>12 )芳氧基-(C<sub> 1 -C </sub>10 )烷基)氨基甲酰氧基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基-N-((C<sub>7</sub>-C<sub>16</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>10</sub>)烷基)氨基甲酰氧基；氨基，(C<sub>1</sub>-C<sub>12</sub>)烷基氨基，二(C<sub>1</sub>-C<sub>12</sub>)烷基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基，(C<sub>3</sub>-C<sub>12</sub>)链烯基氨基，(C<sub>3</sub>-C<sub>12</sub>)链炔基氨基，N-(C<sub>6</sub>-C<sub>12</sub>)芳基氨基，N-(C<sub>7</sub>-C<sub>11</sub>)芳烷基氨基，N-烷基-芳烷基氨基，N-烷基-芳基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷氧基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基；(C<sub>1</sub>-C<sub>12</sub>)烷酰基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基氨基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基氨基，(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基氨基，(C<sub>1</sub>-C<sub>12</sub>)烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基，(C<sub>7</sub>-C<sub>11</sub>)芳烷酰基-N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基；(C<sub>1</sub>-C<sub>12</sub>)烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>6</sub>-C<sub>12</sub>)芳酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基氨基-(C<sub>1</sub>-C<sub>8</sub>)烷基，氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，N-(C<sub>1</sub>-C<sub>10</sub>)烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，N，N-二(C<sub>1</sub>-C<sub>10</sub>)烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基，(C<sub>3</sub>-C<sub>8</sub>)环烷基氨基-(C<sub>1</sub>-C<sub>10</sub>)烷基；(C<sub>1</sub>-C<sub>12</sub>)烷硫基，(C<sub>1</sub>-C<sub>12</sub>)烷基亚磺酰基，(C<sub>1</sub>-C<sub>12</sub>)烷基磺酰基，(C<sub>6</sub>-C<sub>16</sub>)芳硫基，(C<sub>6</sub>-C<sub>16</sub>)芳烷基亚磺酰基，(C<sub>6</sub>-C<sub>16</sub>)芳基磺酰基，(C<sub>7</sub>-C<sub>16</sub>)芳烷硫基，(C<sub>7</sub>-C<sub>16</sub>)芳烷基亚磺酰基或(C<sub>7</sub>-C<sub>16</sub>)芳烷基磺酰基，以及 如果Q表示NR’，则R<sup>4</sup>是R”，其中的R’和R”可相同或不同，表示氢、(C<sub>6</sub>-C<sub>12</sub>)芳基、(C<sub>7</sub>-C<sub>11</sub>)芳烷基、(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>1</sub>-C<sub>8</sub>)烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>7</sub>-C<sub>12</sub>)芳烷氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>6</sub>-C<sub>12</sub>)芳氧基-(C<sub>1</sub>-C<sub>8</sub>)烷基、(C<sub>1</sub>-C<sub>10</sub>)烷酰基、取代或未取代的(C<sub>7</sub>-C<sub>16</sub>)芳烷酰基或取代或未取代的(C<sub>6</sub>-C<sub>12</sub>)芳酰基，或者 R’和R”一起形成-[CH<sub>2</sub>]<sub>h</sub>，其中的CH<sub>2</sub>基可被O、S、N-酰亚胺基或N-(C<sub>1</sub>-C<sub>10</sub>)烷氧基羰基亚氨基代替，以及 f为1至8， g是0或1至(2f+1)， x是0至3， h是3至7， 但不包括3-苄氧基吡啶-2-甲酸(L-苏氨酰)酰胺和3-苄氧基吡啶-2-甲酸((Fmocphg)L-苏氨酰)酰胺的盐酸盐。 | ||
| 地址 | 联邦德国法兰克福 | ||