发明名称 |
Melanoma associated antigenic polypeptide, epitopes thereof and vaccines against melanoma. |
摘要 |
The present invention describes a melanoma associated antigen known as gp100. Furthermore, peptides derived form said antigen are claimed. Gp100 and its peptides can be used in vaccines for the treatment of melanoma. Another aspect of the invention are host cells capable of expression of gplOO or the gp100-derived peptides. Furthermor, tumor infiltrating lymphocytes (TIL's) specifically recognizing gp100 are claimed, as are vaccines with these TIL's. Furthermore, diagnostics for the detection of melanoma and for the monitoring of vaccination form part of the invention. |
申请公布号 |
EP0668350(A1) |
申请公布日期 |
1995.08.23 |
申请号 |
EP19950200348 |
申请日期 |
1995.02.14 |
申请人 |
AKZO NOBEL N.V. |
发明人 |
ADEMA, GOSSE JAN;FIGDOR, CARL GUSTAV |
分类号 |
G01N33/574;A61K35/12;A61K39/00;A61K39/395;A61K48/00;A61P35/00;C07K14/47;C07K14/52;C07K14/705;C07K14/82;C07K16/00;C07K16/32;C12N5/06;C12N5/10;C12N15/09;C12N15/12;C12N15/85;C12P21/02;C12P21/08;C12Q1/68;C12R1/91;G01N33/53 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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