Substituted heterocyclic derivative having squalene epoxidase inhibition action and its use

摘要

PCT No. PCT/JP93/00723 Sec. 371 Date Feb. 11, 1994 Sec. 102(e) Date Feb. 11, 1994 PCT Filed May 28, 1993 PCT Pub. No. WO93/24478 PCT Pub. Date Dec. 9, 1993.Substituted heterocyclic derivatives represented by the formula (I) <IMAGE> (1) wherein R, R1, R2, R3, R4, Q1, Q2, Q3, Q4, X and Y are as defined, including, specifically, the compound (E)-3-[3-[3-(2-methoxymethyl-8,8-dimethyl-4-nonen-6-ynyl)phenoxymethyl]phenyl]thiophene, exhibit squalene epoxidase inhibiting activity and are useful in the treatment or prophylaxis of hypercholesterolemia, hyperlipidemia and arteriosclerosis.