METHOD FOR THE PREPARATION OF BRANCHED CYCLOMALTOOLIGOSACCHARIDES, IN PARTICULAR, BRANCHED CYCLODEXTRINES

摘要

Method for the preparation of branched cyclomaltooligosaccharides, in particular, branched cyclodextrines. The method comprises the steps of reacting a cyclomaltooligosaccharide, for example, a cyclodextrine, with at least one reducing agent selected from monosaccharides, reducing oligosaccharides, reducing polysaccharides and derivatives thereof, in the presence of anhydrous hydrogen fluoride, in order to substitute the hydroxyl groups in the cyclomaltooligosaccharide with the reducing agent, for example, glucose, maltose, mannose and 2-acetoamido-2-deoxy-D-glucose. According to the invention, the solubility in water of the starting cyclooligossacharide is enhanced by this method, while conferring to said substance useful environment-recognizable properties, for conveying therapeutic agents to the required site.