PROCESS FOR PRODUCING HEXAHYDROPYRIDAZINE AND HEXAHYDROPYRIDAZINE-1,2-DICARBOXYLATE DERIVATIVE

摘要

A process for producing a hexahydropyridazine-1,2-dicarboxylate derivative represented by general formula (3) (wherein R<1> and R<2> represent each independently alkyl) by reacting a hydrazinedicarboxylate derivative represented by the general formula (1): R<1>OOC-NH-NH-COOR<2> (wherein R<1> and R<2> are each as defined above) with a dihalogenobutane represented by the general formula (2): X<1>-CH2CH2CH2CH2-X<2> (wherein X<1> and X<2> represent each independently halogen) in the presence of an alkali metal hydroxide, characterized by conducting the reaction in an aprotic polar solvent; and a process for producing hexahydropyridazine by decarboxylating the obtained hexahydropyridazine-1,2-dicarboxylate derivative (3), without being isolated, in the presence of an alkali metal hydroxide and a hydrogen donor compound.