Isatine derivates, their preparation and their use as excitatory amino acid receptor antagonist.

摘要

The present patent application discloses compounds having the formula or a pharmaceutically acceptable salt thereof wherein one R<2><1> and R<2><2> is alkyl and the other is hydrogen or both of R<2><1> and R<2><2> are hydrogen; and R<1>, R<2>, R<3>, R<4>, R<1><1>, R<1><2>, R<1><3>, and R<1><4> each independently are hydrogen, halogen, CF3, CN, or NO2; provided that at least one of R<1>, R<2>, R<3>, R<4>, R<1><1>, R<1><2>, R<1><3>, and R<1><4> are different from hydrogen The compounds are useful as in vivo active glutamate antagonists.