New leukotriene b4 derivatives, methods of preparing them and their use as drugs

摘要

PCT No. PCT/EP94/00215 Sec. 371 Date Dec. 4, 1996 Sec. 102(e) Date Dec. 4, 1996 PCT Filed Jan. 27, 1994 PCT Pub. No. WO95/20563 PCT Pub. Date Aug. 3, 1995The invention relates to leukotriene-B4 derivatives of general formula I, (I) in which R1 represents CH2OH, CH3, CF3COOR4CONR5R6, and R3 symbolizes H; C1-C14 alkyl, C3-C10 cycloalkyl optionally substituted singly or multiply; C6-C10 aryl radicals, independently of one another, optionally substituted singly or multiply by halogen, phenyl, C1-C4 alkyl, C1-C4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carbonyl, carboxyl or hydroxy; or a 5- to 6-membered aromatic heterocyclic ring with at least 1 heteroatom, X and Y mean a direct bond, whereby the resulting olefin can be E- or Z-configured or X represents a fluorine atom in alpha - or beta -position, and Y means a hydrogen atom in beta -position.