| 摘要 |
Compounds of formula (I): <IMG> (I) ¢in which: R1 is aryl or aromatic heterocyclic; R2 and R3 are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C1 - C6 alkylthio, phenylthio, C1 - C6 haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R4 is hydrogen, aliphatic acyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, aromatic acyl, alkoxycarbonyl or benzyloxycarbonyl; R5 and R6 are alkyl; and X is oxygen, sulfur or methylene! have calcium channel blocking activity and can serve for the treatment or prophylaxis of cardiovascular diseases and disorders. They may be prepared by reacting a corresponding compound where R4 is hydrogen and the aminoethyl group is replaced by hydrogen with a compound providing the aminoethyl group and then, if required, acylating the product.
|
