Short synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-[C3H3]-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related non radioactive compounds

摘要

This invention concerns the short synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-[C3H3]-4H-thieno [2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related non-radioactive and radioactive compounds. The key step is the regioselective and stereo-controlled methylation of the C-6 ( alpha -sulfone) carbanion in the presence of the monoprotected sulfonamide anion.