INHIBITORS OF POLY(ADP-RIBOSE) SYNTHETASE AND USE THEREOF TO PREVENT NMDA NEUROTOXICITY

摘要

Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.