发明名称 |
PROCESS FOR THE PREPARATION OF A SALT OF CLAVULANIC ACID |
摘要 |
A process for the preparation of a salt of clavulanic acid, wherein clavulanic acid in solution in a wholly or partly water-imiscible organic solvent is contacted in a region of high turbulence and/or shear stress, with a salt precursor compound to form a solution of the salt of clavulanic acid in an aqueous phase, then the organic solvent and aqueous phases are physically separated during a separation step, followed by a further processing step in which the said salt of clavulanic acid is isolated from solution as a solid. |
申请公布号 |
WO9521173(A1) |
申请公布日期 |
1995.08.10 |
申请号 |
WO1995GB00191 |
申请日期 |
1995.01.31 |
申请人 |
SMITHKLINE BEECHAM PLC;COOK, MICHAEL, ALAN;WEBB, GEOFFREY, CLIVE |
发明人 |
COOK, MICHAEL, ALAN;WEBB, GEOFFREY, CLIVE |
分类号 |
C07D491/04;A61K31/42;A61K31/424;A61P43/00;C07D503/00;C07D503/06;C07D503/18 |
主分类号 |
C07D491/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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