发明名称 |
OCTAHYDRONAPHTHALENE OXIME DERIVATIVES FOR CHOLESTEROL SYNTHESIS INHIBITION, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM |
摘要 |
Compounds of formula (I): (I) <IMG> ¢in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y represents hydrogen, or an aryl, cycloalkyl or heterocyclic group! have valuable antihypercholesteremic activities and may be used in the treatment of disorders arising from a blood cholesterol imbalance in humans and other animals. They may be prepared by introducing the group =NO-A-Y in place of an oxygen atom at the 4-position or introducing the group -O-CO-X in place of a hydroxy group at the 1-position in a corresponding compound in which the hydroxy group at the 16 position is protected and deprotecting that group.
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申请公布号 |
CA1336598(C) |
申请公布日期 |
1995.08.08 |
申请号 |
CA19880581504 |
申请日期 |
1988.10.27 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
KURABAYASHI, MASAAKI;KOGEN, HIROSHI;KADOKAWA, HIROSHI;KURIHARA, HIDESHI;HASEGAWA, KAZUO;KURODA, MASAO |
分类号 |
C07C251/44;C07C251/50;C07D295/088;C07D309/30;C07D405/12;C07D407/12;C07D413/12;(IPC1-7):C07C251/44 |
主分类号 |
C07C251/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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