| 摘要 |
The (+)-?-, (-)-?-, (+)-?- and (-)-?- forms of 2-methylspiro(1,3-oxathiolan-5,3')quinuclidine are prepared by optical resolution of each of the (?)-?- and (?)-?-isomers. These compounds find application in treating diseases of the central nervous system in mammals, especially diseases due to a deficiency in the central cholinergic system. Biological tests indicate that the (-)-?-form, as well as the (?)-?-isomer, shows particular promise for treating senile dementia of Alzheimer's type.
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