摘要 |
PURPOSE:To obtain in an industrially advantageous way the subject compound useful as an intermediate for medicines, agrochemicals etc., by reaction of a phenylalkene derivative obtained from a readily available starting material with hydrogen bromide in a nonpolar solvent. CONSTITUTION:This 1-bromoalkylbenzene derivative of formula II can be obtained by reaction of a phenylalkene derivative of formula I (R is H, a halogen, a lower alkyl or a lower alkoxyl; (n) is 1-8) with hydrogen bromide in a nonpolar solvent (pref. tetrahydrofuran singly, or its combination with t-butyl- methyl ether or an aromatic hydrocarbon) pref. in the presence of a radical initiator. The compound of formula I can be prepared by reaction between a compound of formula III (X is Cl or Br), a Grignard reagent prepared from metallic magnesium and a benzyl halide of formula IV, if desired, in the presence of a catalyst (pref. Ni). The compound of formula II is an important intermediate for a compound of formula V. |