发明名称 |
Maleimide adduct conjugates of procainamide and NAPA |
摘要 |
Novel derivatives of procainamide and N-acetylprocainamide (NAPA) are disclosed having the following formula: <IMAGE> +TR <IMAGE> wherein: X=hydrogen or acetyl; R1=an alkyl group having 1 to 3 carbon atoms; m=an integer from 2 to 10; R2=an alkyl, cycloalkyl or aryl group having 2 to 10 carbon atoms; Z=a poly(amino acid); and n=1 to p where p=MW of Z/1000. The derivatives include maleimide conjugates of proteins or poly(amino acids), enzymes, enzyme donor polypeptides and labeling substances. Novel activated hapten intermediates useful in the preparation of the conjugates and methods for synthesis of the hapten intermediates and derivatives are also disclosed.
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申请公布号 |
US5439798(A) |
申请公布日期 |
1995.08.08 |
申请号 |
US19930169851 |
申请日期 |
1993.12.17 |
申请人 |
BOEHRINGER MANNHEIM CORPORATION |
发明人 |
SIGLER, GERALD F.;WALTER, CHARLES F.;DURANT, CHARLES E.;GLANCY, TODD;KLEIN, FRANK E.;DORN, ALLAN R. |
分类号 |
A61K39/385;A61K39/395;C07D207/40;C07D207/416;C07D207/44;C07D207/452;C07K16/44;C08B37/00;C12N9/38;C12N9/96;(IPC1-7):G01N33/542;C07D207/448 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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