(Trans-1,4 dialkoxycyclohexyl) substituted arylalkylaryl-,arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase

摘要

Compounds of structure where W is selected from the group consisting of where Q is oxygen or sulfur, R7 and R8 are independently selected from hydrogen and alkyl, or R7 and R8, together with the nitrogen atoms to which they are attached, define a radical of formula L1 and L2 are independently selected from a valence bond, alkylene, propenylene, and propynylene; R1, R2, R3, and R4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is oxygen, >NR11, where R11 is hydrogen or alkyl, or where n=0, 1, or 2; and R5 and R6 are alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.